Tianjin Institute of Life Sciences Applications

Product Info

Hemin (porphyrin iron)

SOD (SUPEROXIDE DISMUTASE)

LA-SOD (Modified SOD)

Product Profile

Product Name:Hemin (porphyrin iron)

I) Hemin (iron porphyrin or porphyrin iron) products
　　Hemin (porphyrin iron) is extracted from fresh blood erythrocyte in the body of pig or cattle by using advanced enzyme engineering, having good quality and high purity.

1. Properties: blue-black fine flaky crystalline; nearly insoluble in water and insoluble in diluted acid solution, but soluble in sig water and dilute ammonia water; infusible even heated up to 300℃.
2. Purity: 92~98%.
3. Molecular formula: C34H32ClFeN4O4, molecular weight: 651.96
4. Stability: it will keep for two years away from light under normal temperature.
　　Heme, a substance importing O2 and CO2 into human body, combines with protein to be hemoglobin. Existing in the cell in a state of biological iron, it is a natural iron supplement to treat iron-deficiency anemia and could be easily absorbed by human body. Without toxic action or side effect, even pregnant women or children can take it safely. As it could be absorbed and utilized by intestinal mucosa, the rate of absorption is up to 25% or above. After taking it, the increase of hemoglobin in a short time enhances the erythrocyte and improve anemia quickly. Current iron supplement products made of hemin approved by the Ministry of Health are in the forms of capsule, tablets and oral liquid, applicable for the treatment of iron-deficiency anemia and thalassemia.

(II). Blood enrichment products made of other substances are generally born with toxic action or side effect.
　　The French is the earliest to treat iron-deficiency anemia with FeSO4, ending up with a low rate of absorption only at 1~3% and an obvious side effect bothering the stomach and intestines.
　　With the further research on free radical medicines that came into existence over recent 15 years, it is found that the ferrous sulfate, ferrous lactate, ferrous maltonic acid and similar substances can dissociate Fe2+ in the aqueous solution and body fluid, as a result of generating oxygen-derived free radicals harmful to body. The equation of the above reaction is: Fe2++O2 ?Fe3++Oˉ2. As a weak reducer, the free Fe2+ sends its electron to O2 in the body fluid and the resultant Oˉ2 is harmful to the body. In addition, Fe2+ and Fe3+ will react with H2 and O2 as soon as they meet together and give birth to ?OH (hydroxy radical) and O2-, both of which may seriously harm the organic body. Therefore, products made of substances with such iron ions will bother the stomach and intestines and give birth to more free radicals through chain reaction of free radicals in the body. In this case, many cells and internal organs will be harmed and long-time taking will cause patients to suffer diseases resulted from increasing free radicals and quick aging in their middle and old ages.

(III) About iron-deficiency anemia
　　As shown in data released by WHO in 1990s, there were 21.5 billion people were suffering from iron deficiencies, of which 11.2 billion people were in trouble with anemia. The rate of incidence of anemia was 47% for common women, 60% for pregnant women, 33.8~45.7% for infants from 6 months to 3 years old and over 33% for students in elementary and secondary schools. Therefore, WHO made much account of the iron-deficiency anemia as it is a major cause significantly affecting people’s health throughout the world and the Military of Health and National Education Commission in China had listed it to be key disease to be prevented and controlled for children. It is common for people to neglect the iron-deficiency anemia because they are attacked chronically. The disease is reflected in clinic as tiredness, lack of strength, deficiency of vital energy, hard breathing and chlorosis, affecting normal work and life. Once attacked, children will suffer from abnormal body and intellectual growth, which is the most terrible case with regard to iron deficiency.
　　We’re sincerely your application of hemin (iron porphyrin or porphyrin iron) in the development of new blood supplement products, accordingly making a contribution to the patients suffering from anemia and national health business.

(IV). Hemin quality standard:
      Sense: blue-black crystalline power,
      odorless and colorless
      Purity: >95% or above
      H2O ≤2.0%
      Fe≥8.16%－8.4%
      Physical and chemical indicator:
      Lead (Pb) ≤0.5mg/Kg
      Arsenic (As) ≤0.3mg/Kg
      Hydrargyrum (Hg) ≤0.3mg/Kg